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Overeating after fasting = fat gain – Thomas DeLauer
A study published in the journal Cell found that overeating has a damaging effect on the body's metabolism, since it can destroy your body's normal metabolic response.
In your body there is a molecule called RNA-dependent protein kinase, or PKR, which signals and fights viruses with other molecules, but if you eat too much, it also attacks the metabolism.
When you eat too much, the excess nutrients attack the cells that contain PKR, and your response is to fight the metabolism because all these additional nutrients are perceived as a threat.
This can lead to metabolic disorders such as diabetes and obesity.
Note: Although the study was conducted in mice, the researchers stated that it gives them a better understanding of PKR and the side effects of overeating
Overeating in mice triggers a molecule that was once considered to be only involved in detection and fights against viruses to also destroy normal metabolism, leading to insulin resistance and setting the stage for diabetes
When mice eat a normal diet, this molecule called PKR is silent; however, if a cell containing PKR is bombarded with too many nutrients, PKR takes other molecules of the immune system that respond to this food attack and organizes a "firing squad" to bring down normal processes, leading to insulin resistance and metabolic dysfunction
The results provide evidence that a process called "metaflammation" occurs in the body: metaflammation is an inflammation that is triggered by the metabolism of nutrients that occurs when the body processes food into energy.
It is known that nutrients can be harmful in excessive amounts or when they are in the wrong place at the wrong time, but what is not so clear is what roads run, cause damage and produce inflammation.
PKR is a mechanism by which nutrients, necessary and beneficial under normal conditions, cause damage to cells and organs. "
The researchers used sets of mice in their experiments: one had PKR in their bodies and the other did not.
Then, the researchers superimposed a group of diets rich in fats and rich in PKR-positive and PKR-negative.
PKR-supercharged mice became obese and developed insulin resistance, while supercharged mice without PKR gained significantly less weight and did not develop insulin resistance, indicating that the absence of PKR can alleviate the deleterious metabolic effects due to the overfeeding in mice
Overeating and brain function
Brain insulin is what suppresses lipolysis, a process during which triglycerides in fat tissue are broken down and fatty acids are released.
When lipolysis is not restricted, the levels of fatty acids are high
Once you overeat, your brain develops insulin resistance, since brain insulin controls lipolysis in adipose tissue by reducing the exit of the sympathetic nervous system to adipose tissue, insulin resistance in the brain causes a greater spilling of fatty acids from adipose tissue into the bloodstream
In this study, published in the Journal of Biological Chemistry, researchers fed rats with a high-fat diet consisting of 10% lard for three consecutive days
This increased their daily caloric intake by up to 50% compared to the control rats that were fed a regular low-fat diet
The researchers then infused a small amount of insulin into the brains of both groups of rats that had been shown in previous studies to suppress the release of glucose from the liver and fatty acids from fat tissue.
They found that overeating affected the brain's ability to suppress the release of glucose from the liver and lipolysis in fat tissue.
Video credits to Thomas DeLauer YouTube channel