In the last half century (an extremely short period of evolutionary time), the incidence of obesity and type 2 diabetes has gone from being non-existent in most of the world to more than 50% of the population. Intensive research on possible genetic defects responsible for this pandemic supports the argument that all genetic defects discovered that predispose to the metabolic syndrome may only represent about 5% of the total incidence. How could such a pandemic grow so rapidly in all the ethnic and cultural origins of the geographical world? Research from the VeroScience laboratory and many others point to important roles for the body's biological clock systems that evolved to regulate metabolism in anticipation of the following seasons of food shortage or abundance. Said clock mechanisms are responsible for the actual SEASONAL induction of the obese insulin resistance state (for survival against the low glucose supply to the brain during the seasons when there is no natural availability in nature) as well as for its reversal in the appropriate seasons of the year when food is scarce and plentiful, respectively. The mechanism of the watch also responds to the signs of "stress" of the Westernized lifestyle from a diet high in fat, altered sleep cycles, social stress and altered photoperiod to take the animal to the "survival mode" of the state of insulin resistance. Unfortunately, such persistent stress "blocks" the individual in the obese insulin resistant seasonal condition throughout the year, which eventually leads to a metabolic pathology of diabetes and cardiovascular disease. Restoring this clock system (from the seasonal insulin-resistant to insulin-sensitive organization) is a method to improve this pathology.
Video credits to WebsEdgeHealth YouTube channel