Intermittent fasting vs. prolonged fasting: benefits of 1-3 days. Thomas DeLauer … Learn some of my fasting protocols with me 1: 1
The prolonged fasting (FP) is the one that lasts from 48 hours to 120 hours-
Studies have found that fasting:
Reduces oxidative damage and inflammation
Promotes optimal energy metabolism
In humans the benefits include:
Benefits of arthritis
Help with hypertension
Prolonged fasting has been shown to:
Increases cellular resistance to toxins in studies in humans and mice
Reduces circulating growth factor similar to insulin 1 (IGF-1)
Protect the cells from chemotoxicity (for example, those that undergo chemotherapy)
The differences between FP and fasting of less than 24 hours are probably due to total glycogen depletion. Our liver stores most of the glucose in our body as glycogen.
After 12 or 24 hours of fasting (varies by person and factors such as physical form), liver (hepatic) glycogen stores are depleted and the body resorts to the following for energy:
Non-hepatic glycogen stores
Free fatty acids
Humans can survive 30 or more days by fasting. This way of producing energy can delay cellular aging in mammals. It is natural for humans to have a lot of energy when they are hungry and less energy when they are sated, probably because we would have needed our brains to work well to find new sources of food.
Hunger creates a cascade of bodily processes that can explain the benefits of fasting. When we are hungry, certain hormones are released and neuronal networks are activated. The response to hunger leads to greater activity in neural networks related to cognition.
This leads to:
Production of BDNF (neurotrophic factor derived from the brain)
Improvement of synaptic plasticity
Increased tolerance to stress
The cardiovascular benefits are probably due to high adiponectin levels during fasting
Adiponectin is released from fat cells. Obese people have less circulating adiponectin than people of normal weight. Very little adiponectin is linked to many chronic diseases, including type 2 diabetes, metabolic syndrome, nonalcoholic fatty liver disease, cancer and heart disease. Adiponectin in an anti-inflammatory agent and protects against chronic disease. Hypertension has been helped in a study in humans with 13 days of fasting alone in water, and the benefits were even maintained when the blood pressure was analyzed after 6 days of eating normally. Fasting for 3 or more days produces changes in insulin, IGF-1, IGFBP-1 and glucose:
30% or more decrease in plasma insulin and glucose levels
Decrease in IGF-1, the main growth factor in humans
High levels of IGF-1 and insulin are related to aging and cancer
Increase in IGFBP-1 (a protein that inhibits IGF-1)
Longer fasting periods have shown impressive results for those with rheumatoid arthritis
The best results are with a fasting period of 1-3 weeks followed by a vegetarian diet.
Benefit of the immune system:
Fasting for 3 days or more leads to a restart of the immune system
Fasting reduces white blood cell counts, which causes the immune system to create new white blood cells
One study took cancer patients who were receiving chemotherapy and had them fast for 1, 2 or 3 days before chemotherapy.
Those who fasted for 3 days, but not those who fasted for 1 day, experienced fewer harmful side effects, such as immunosuppression. Many positive effects have been found in both prolonged fasting and intermittent fasting, so it is likely that they will be incorporated into your routine to be beneficial
* It is very important to talk with your doctor before going to a quick session of 3 or more days. Longer fasts may not be advisable for those underweight, young or old.
1. Prolonged fast reduces IGF-1 / PKA to promote …
2. Fasting: molecular mechanisms and clinical applications
Video credits to Thomas DeLauer YouTube channel