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Does a high-fat diet cause inflammation? (Diet and inflammation of Keto) – Thomas DeLauer
bHB and inflammation
Beta-hydroxybutyrate can block what is known as the NLRP3 inflammasome, an immune system receptor linked to inflammation.
The NLRP3 inflammasome reacts quickly to threats to the body, such as toxins, infections or too much glucose.
While it is useful in many cases, this receptor can become too active if we are constantly exposed to inflammation, such as by eating inflammatory foods every day.
By triggering ketosis, we can help reduce the amount of NLRP3 that triggers in the body.
A ketogenic diet could be beneficial for several types of pain, including neuropathic pain and inflammatory pain. Compared to glucose metabolism, ketone metabolism produces fewer reactive oxygen species, which are known to contribute to inflammation.
Ketosis and 2-deoxyglucose (2DG): Brain inflammation
Study: Raymond Swanson, MD, professor of neurology at UCSF, head of the neurology service at the San Francisco Veterans Affairs Medical Center and lead author of the new study
The researchers used a small molecule called 2-deoxyglucose, or 2DG, to block the metabolism of glucose and produce a ketogenic state in rats and controlled laboratory cell lines.
He discovered that 2DG could reduce levels of inflammation to almost control levels: the 2DG molecule prevented glucose from being metabolized and created a ketogenic state in rodents with brain inflammation, as well as in cell cultures. As a result, the levels of inflammation were drastically reduced, almost to healthy levels.
It was also found that the reduction of glucose metabolism decreased a key barometer of energy metabolism, the NADH / NAD + ratio, which in turn activated a protein called CtBP that acts to suppress the activity of inflammatory genes.
The researchers designed a peptide molecule similar to a drug that blocks the ability of CtBP to enter its inactive state: essentially forcing the protein to constantly block the activity of inflammatory genes and mimicking the effect of a ketogenic state
The study has applications beyond brain-related inflammation: the presence of excess glucose in people with diabetes, for example, is associated with a proinflammatory state that often leads to atherosclerosis, the accumulation of fat plaques that They can block the key arteries.
1) Ketosis for Reduced Inflammation. (2017, July 13). Retrieved on January 4, 2018, from
2) Masino, S. A., and Ruskin, D. N. (2013, August). Ketogenic diets and pain. Retrieved on January 4, 2018, from
3) UC San Francisco. (2018). How ketogenic diets slow down inflammation in the brain. [online] Available in:
Video credits to Thomas DeLauer YouTube channel